1.Date of occurrence of the change:2024/04/12

2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director, natural-person director or natural-person supervisor):institutional director、natural-person director、institutional supervisor

3.Title and name of the previous position holder:
(1)Director：Representative of TTY BIOPHARM COMPANY LIMITED：Sze-Yuan Yang
(2)Director：Representative of TTY BIOPHARM COMPANY LIMITED：Jui-Wen Wu
(3)Director：Representative of TSH Biopharm Corporation Limited：Carl Hsiao
(4)Supervisor：Kuo-Chiang Chang
(5)Supervisor：Jung-Liang Kao

4.Resume of the previous position holder:
(1)Sze-Yuan Yang：General Manager of TSH Biopharm Corporation Limited
(2)Jui-Wen Wu：Chairman's Special Assistant of TTY BIOPHARM COMPANY LIMITED
(3)Carl Hsiao：Director of TTY BIOPHARM COMPANY LIMITED
(4)Kuo-Chiang Chang：Corporate governance officer of TTY BIOPHARM COMPANY LIMITED
(5)Jung-Liang Kao：CFO of TSH Biopharm Corporation Limited

5.Title and name of the new position holder:
(1)Director：Representative of TSH Biopharm Corporation Limited: Sze-Yuan Yang
(2)Director：Representative of TSH Biopharm Corporation Limited: Carl Hsiao
(3)Director：Jing-Ping Liou
(4)Supervisor：Representative of TTY BIOPHARM COMPANY LIMITED:Kuo-Chiang Chang

6.Resume of the new position holder:
(1)Sze-Yuan Yang：General Manager of TSH Biopharm Corporation Limited
(2)Carl Hsiao：Director of TTY BIOPHARM COMPANY LIMITED
(3)Jing-Ping Liou：Dean, Research and Development, Taipei Medical University
(4)Kuo-Chiang Chang：Corporate governance officer of TTY BIOPHARM COMPANY LIMITED

7.Circumstances of change (Please enter “resignation”, “dismissal”,“term expired”, “death” or “new appointment”): new appointment

8.Reason for the change:Early re-election of directors and supervisors

9.Number of shares held by the new position holder when elected:
(1)Director：TSH Biopharm Corporation Limited(Representative：Sze-Yuan Yang)：16,590,279 shares；
(2)Director：TSH Biopharm Corporation Limited(Representative：Carl Hsiao)：16,590,279 shares；
(3)Jing-Ping Liou：0 share
(4)Supervisor：TTY BIOPHARM COMPANY LIMITED(Representative：Kuo-Chiang Chang)：7,432,299 shares

10.Original term (from __________ to __________):2022/05/31~2025/05/30

11.Effective date of the new appointment:2024/04/12~2027/4/11

12.Turnover rate of directors of the same term:NA.

13.Turnover rate of independent directors of the same term:NA.

14.Turnover rate of supervisors of the same term:NA.

15.Change in one-third or more of directors (Please enter “Yes” or“No”):No

16.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6 of the Securities and Exchange Act Enforcement Rules, which brings forth a significant impact on shareholders rights or the price of the securities on public companies.):None