1.Date of occurrence of the change:2024/04/24

2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director, natural-person director or natural-person supervisor):institutional director、natural-person director、natural-person supervisor

3.Title and name of the previous position holder:
(1)Director：Ching-Hua Gu
(2)Director：Min-Li Wei
(3)Director：Shih-Cheng Lai
(4)Supervisor：ANIMATO INTERNATIONAL COMPANY

4.Resume of the previous position holder:
(1)Ching-Hua Gu：Chairman of TOP PHARM. MEDICALWARE COMPANY LIMITED
(2)Min-Li Wei：General Manager of TOP PHARM. MEDICALWARE COMPANY LIMITED
(3)Shih-Cheng Lai：Deputy General Manager of TOP PHARM. MEDICALWARE COMPANY LIMITED
(4)ANIMATO INTERNATIONAL COMPANY：Supervisor of TOP PHARM. MEDICALWARE COMPANY LIMITED

5.Title and name of the new position holder:
(1)Director：Representative of TSH Biopharm Corporation Limited：Sze-Yuan Yang
(2)Director：Jui-Wen Wu
(3)Director：Lai-Shou Su
(4)Director：Min-Li Wei
(5)Director：Shih-Cheng Lai
(6)Supervisor：Ching-Hua Gu
(7)Supervisor：Jung-Liang Kao

6.Resume of the new position holder:
(1)Sze-Yuan Yang：General Manager of TSH Biopharm Corporation Limited
(2)Jui-Wen Wu：Senior Director of TTY BIOPHARM COMPANY LIMITED
(3)Lai-Shou Su：Director of Taiwan Bio-Manufacturing Corporation
(4)Min-Li Wei：General Manager of TOP PHARM. MEDICALWARE COMPANY LIMITED
(5)Shih-Cheng Lai：Deputy General Manager of TOP PHARM. MEDICALWARE COMPANY LIMITED
(6)Ching-Hua Gu：Chairman of TOP PHARM. MEDICALWARE COMPANY LIMITED
(7)Jung-Liang Kao：CFO of TSH Biopharm Corporation Limited

7.Circumstances of change (Please enter “resignation”, “dismissal”,“term expired”, “death” or “new appointment”):new appointment

8.Reason for the change:re-election of directors and supervisors

9.Number of shares held by the new position holder when elected:
(1)Director：TSH Biopharm Corporation Limited(Representative：Sze-Yuan Yang)：2,157,300 shares
(2)Director：Jui-Wen Wu：0 shares
(3)Director：Lai-Shou Su：0 shares
(4)Director：Min-Li Wei：180,000 shares
(5)Director：Shih-Cheng Lai：0 shares
(6)Supervisor：Ching-Hua Gu：5,000 shares
(7)Supervisor：Jung-Liang Kao：0 shares

10.Original term (from __________ to __________):2022/08/25~2025/08/24

11.Effective date of the new appointment:2024/04/24~2027/04/23

12.Turnover rate of directors of the same term:NA.

13.Turnover rate of independent directors of the same term:NA.

14.Turnover rate of supervisors of the same term:NA.

15.Change in one-third or more of directors (Please enter “Yes” or“No”):No

16.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6 of the Securities and Exchange Act Enforcement Rules, which brings forth a significant impact on shareholders rights or the price of the securities on public companies.):None