1.Date of occurrence of the change:2023/05/25

2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director, natural-person director or natural-person supervisor):Institutional director and independent director

3.Title and name of the previous position holder:
(1)Director:Representative of TTY Biopharm Company Limited:Chuan Lin
(2)Director:Representative of TTY Biopharm Company Limited:Carl Hsiao
(3)Director:Representative of TTY Biopharm Company Limited:Chao-I Chiang
(4)Director:Representative of TTY Biopharm Company Limited:Kang-Chi Chou
(5)Independent Director:Chih-Li Wang
(6)Independent Director:Rwei-Syun Chen
(7)Independent Director:Yaw-Bin Huang

4.Resume of the previous position holder:
(1)Chuan Lin:Chairman of TTY Biopharm Company Limited
(2)Carl Hsiao:Director of TTY Biopharm Company Limited
(3)Chao-I Chiang:Remuneration Committee member of PharmaEngine Inc.
(4)Kang-Chi Chou:Chairman and President of IROC CO., LTD.
(5)Chih-Li Wang:Partner CPA of Moores Rowland CPAs
(6)Rwei-Syun Chen:Independent Director of Welgene Biotech Co., Ltd.
(7)Yaw-Bin Huang:Dean of the School of Pharmacy, Kaohsiung Medical University

5.Title and name of the new position holder:
(1)Director:Representative of TTY Biopharm Company Limited:Chuan Lin
(2)Director:Representative of TTY Biopharm Company Limited:Carl Hsiao
(3)Director:Representative of TTY Biopharm Company Limited:Kang-Chi Chou
(4)Director:Representative of TTY Biopharm Company Limited:Yong-Liang Wu
(5)Independent Director:Te-Yu Chou
(6)Independent Director:Rwei-Syun Chen
(7)Independent Director:Yaw-Bin Huang

6.Resume of the new position holder:
(1)Representative of TTY Biopharm Company Limited:Chuan Lin:Chairman of TTY Biopharm Company Limited
(2)Representative of TTY Biopharm Company Limited:Carl Hsiao:Director of TTY Biopharm Company Limited
(3)Representative of TTY Biopharm Company Limited:Kang-Chi Chou:Chairman and President of IROC CO., LTD.
(4)Representative of TTY Biopharm Company Limited:Yong-Liang Wu:Supervisor of Dawan Technology Co., Ltd.
(5)Te-Yu Chou:Independent Director of Taiwan Cooperative Bank
(6)Rwei-Syun Chen:Independent Director of Welgene Biotech Co., Ltd.
(7)Yaw-Bin Huang:Dean of the School of Pharmacy, Kaohsiung Medical University

7.Circumstances of change (Please enter “resignation”, “dismissal”,“term expired”, “death” or “new appointment”):Term expired

8.Reason for the change:Re-election of the Board of Directors

9.Number of shares held by the new position holder when elected:
(1)Director:TTY Biopharm Company Limited(Representative:Chuan Lin); 21,687,177 shares
(2)Director:TTY Biopharm Company Limited(Representative:Carl Hsiao); 21,687,177 shares
(3)Director:TTY Biopharm Company Limited(Representative:Kang-Chi Chou); 21,687,177 shares
(4)Director:TTY Biopharm Company Limited(Representative:Yong-Liang Wu); 21,687,177 shares
(5)Independent Director:Te-Yu Chou;0 shares
(6)Independent Director:Rwei-Syun Chen;0 shares
(7)Independent Director:Yaw-Bin Huang;0 shares

10.Original term (from __________ to __________):2020/05/29~2023/05/28

11.Effective date of the new appointment:2023/05/25

12.Turnover rate of directors of the same term:NA.

13.Turnover rate of independent directors of the same term:NA.

14.Turnover rate of supervisors of the same term:NA.

15.Change in one-third or more of directors (Please enter “Yes” or“No”):No.

16.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6 of the Securities and Exchange Act Enforcement Rules, which brings forth a significant impact on shareholders rights or the price of the securities on public companies.):None.